Publication

Ultra-deep sequencing reveals intra-host diversity and co-infection-driven evolution of SARS-CoV-2

Carol Moraga, Francisco Kirhman, Barbara Bernal, Sofia Poblete, Pastor Jullian, Adrian Gonzalez, Mauricio Latorre, Alex Di Genova

January 2026 bioRxiv
Abstract

Study summary

This preprint uses ultra-deep whole-genome sequencing of SARS-CoV-2 samples from Chile to characterize intra-host variation, low-frequency mutations, co-infections, and variant-level evolutionary dynamics. The study shows how high-depth viral sequencing can reveal early diversification processes that are invisible to consensus-only surveillance.