Publication

TERT expression and clinical outcome in pulmonary carcinoids

Lisa Werr, Christoph Bartenhagen, Carolina Rosswog, Maria Cartolano, Catherine Voegele, Alexandra Sexton-Oates, Alex Di Genova, Angela Ernst, Yvonne Kahlert, Nadine Hemstedt, Stefanie Hoppner, Audrey Mansuet Lupo, Giuseppe Pelosi, Luka Brcic, Mauro Papotti, Julie George, Graziella Bosco, Alexander Quaas, Laura H. Tang, Kenneth Robzyk, Kyuichi Kadota, Mee Sook Roh, Rachel E. Fanaroff, Christina J. Falcon, Reinhard Buttner, Sylvie Lantuejoul, Natasha Rekhtman, Charles M. Rudin, William D. Travis, Nicolas Alcala, Lynnette Fernandez-Cuesta, Matthieu Foll, Martin Peifer, Roman K. Thomas, Matthias Fischer, Lung NEN Network

January 2025 Journal of Clinical Oncology
Abstract

Study summary

Across discovery and validation cohorts, this work shows that TERT expression separates pulmonary carcinoids into biologically and clinically distinct groups. High TERT expression is associated with more aggressive disease behavior and poorer outcome, supporting TERT as a practical prognostic marker in these tumors.