RFhap is a reproducible workflow for haplotype-resolved de novo assembly of human genomes using parental short reads and child long reads. The method assigns long reads to parental haplotypes and evaluates downstream assemblies with haplotype-aware …
This preprint uses ultra-deep whole-genome sequencing of SARS-CoV-2 samples from Chile to characterize intra-host variation, low-frequency mutations, co-infections, and variant-level evolutionary dynamics. The study shows how high-depth viral …
This preprint integrates genomics, transcriptomics, methylation, spatial profiling, morphology, and clinical data to refine the classification of lung neuroendocrine tumours. The proposed morpho-molecular groups expose clinically relevant tumour …
This preprint examines how willow and pine growth alters the physicochemical and microbial environment of copper mine tailing soils. Vegetated sites showed reduced copper stress, more neutral pH, shifts in bacterial abundance and interaction …
This preprint investigates physiological and genomic adaptations that allow Cistanthe longiscapa to survive in the Atacama Desert. The study links photosynthetic performance, CAM-related signals, genome features, and stress-response gene family …